We have developed much understanding of actin-driven cell migration and the forces that propel cell motility.However, fewer studies focused on estimating the effective forces generated by migrating cells.Since cells in vivo are exposed to complex physical environments with various barriers, ORG FARRO understanding the forces generated by cells will
Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort
Purpose The Lifelines COVID-19 cohort was set up to assess the psychological and societal impacts of the COVID-19 pandemic and investigate potential risk factors for COVID-19 within the Lifelines prospective population cohort.Participants Participants were recruited from the 140 000 eligible participants of Lifelines and the Lifelines NEXT birth co
Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat
Recent studies suggest that calcitonin gene-related peptide (CGRP) neurons in the parabrachial nucleus (PBN) represent aversive information and signal a general alarm to the forebrain.If CGRP neurons serve as a true general alarm, their activation would modulate both passive and active defensive behaviors depending on the magnitude and context of t